Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2018 English Publisher:Elsevier BVJournal:Clinical Immunology, volume 197, pages 77-85 (issn: 1521-6616,

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Authors: Mei, Wang; Fuqiong, Chen; Jingli, Wang; Zhixuan, Zeng; Qin, Yang; Shiying, Shao;

doi: 10.1016/j.clim.2018.09.005

pmid: 30218707

Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients

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Abstract

Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM) encompasses inflammation and autoimmune aspects is increasingly recognized. In the state of obesity and T2DM, the imbalance of T helper 17 (Th17) cells and regulatory T (Treg) cells are observed. These alterations reflect a loss of T cell homeostasis, which may contribute to tissue and systemic inflammation and immunity in T2DM. In this review we will discuss the accumulating data supporting the concept that Th17/Treg mediated immune responses are present in obesity-related T2DM pathogenesis, and provide evidences that restoration of Th17/Treg imbalance may be a possible therapeutic avenue for the prevention and treatment of T2DM and its complications.

Related Organizations

Tongji Hospital
China (People's Republic of)
Jingzhou Central Hospital
China (People's Republic of)
Huazhong University of Science and Technology
China (People's Republic of)

Keywords

Inflammation, Diabetes Mellitus, Type 2, Humans, Th17 Cells, Obesity, T-Lymphocytes, Regulatory

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