Granzyme B producing B-cells in renal transplant patients
Copyright policy )Granzyme B producing B-cells in renal transplant patients
A separate subset of Granzyme B (GrB) producing B-cells regulating T-cell mediated immunity has been identified. In the present study, we investigated the role of GrB+ B-cells in renal transplant patients (RTX).12 healthy controls (HC) and 26 RTX patients were enrolled. In addition, 19 healthy volunteers treated with cyclosporine A (CsA) were enrolled. GrB+ B-cells were determined via flow cytometry.RTX Patients showed a diminished fraction of GrB+ B-cells as compared to HC. CsA treatment of healthy volunteers had no impact on the development of GrB+ B-cells. RTX patients with a history of allograft rejection showed an increased frequency of GrB+ B-cells. RTX patients with at least one episode of CMV viremia tended to have lower GrB+ B-cells as compared to patients without viremic episodes.We demonstrate that treatment with CsA does not impair the development of GrB+ B-cells. GrB+ B-cells may have a dual role in renal transplantation as regulatory cells to maintain allospecific tolerance and as effector cells enhancing viral control.
- University of Duisburg-Essen Germany
- Wuhan Children's Hospital China (People's Republic of)
- Essen University Hospital Germany
- Huazhong University of Science and Technology China (People's Republic of)
Graft Rejection, Male, B-Lymphocytes, Interleukins, Medizin, Middle Aged, Mycophenolic Acid, Kidney Transplantation, Granzymes, Tacrolimus, Interleukin-21, Adrenal Cortex Hormones, Case-Control Studies, Cyclosporine, Humans, Female, Immunosuppressive Agents, Aged
Graft Rejection, Male, B-Lymphocytes, Interleukins, Medizin, Middle Aged, Mycophenolic Acid, Kidney Transplantation, Granzymes, Tacrolimus, Interleukin-21, Adrenal Cortex Hormones, Case-Control Studies, Cyclosporine, Humans, Female, Immunosuppressive Agents, Aged
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).23 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!