Microbial Modulation of a Uremic Toxin

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2016 English Publisher:Elsevier BVJournal:Cell Host & Microbe, volume 20, pages 691-692 (issn: 1931-3128,

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Authors: Sarah M, Skye; Stanley L, Hazen;

doi: 10.1016/j.chom.2016.11.005

pmid: 27978427

Microbial Modulation of a Uremic Toxin

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Abstract

In this issue of Cell Host & Microbe, Devlin et al. (2016) identify a family of tryptophanases encoded by members of the human gut microbiome and demonstrate that levels of the uremic toxin indoxyl sulfate can be modulated in vivo by altering the abundance of bacteria harboring tryptophanase activity.

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Cleveland Clinic
United States

Keywords

Bacteria, Bacterial Toxins, Tryptophanase, Kidney, Biological Evolution, Diet, Gastrointestinal Microbiome, Liver, Cardiovascular Diseases, Animals, Humans, Symbiosis, Indican, Uremia

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