Bmp4 Promotes a Brown to White-like Adipocyte Shift
Copyright policy )Bmp4 Promotes a Brown to White-like Adipocyte Shift
While Bmp4 has a well-established role in the commitment of mesenchymal stem cells into the adipogenic lineage, its role in brown adipocyte formation and activity is not well defined. Here, we show that Bmp4 has a dual function in adipogenesis by inducing adipocyte commitment while inhibiting the acquisition of a brown phenotype during terminal differentiation. Selective brown adipose tissue overexpression of Bmp4 in mice induces a shift from a brown to a white-like adipocyte phenotype. This effect is mediated by Smad signaling and might be in part due to suppression of lipolysis, via regulation of hormone sensitive lipase expression linked to reduced Ppar activity. Given that we observed a strong correlation between BMP4 levels and adipocyte size, as well as insulin sensitivity in humans, we propose that Bmp4 is an important factor in the context of obesity and type 2 diabetes.
Cell Reports, 16 (8)
ISSN:2666-3864
ISSN:2211-1247
- Institute of Food, Nutrition, and Health Switzerland
- Slovak Academy of Sciences Slovakia
- Comenius University Slovakia
- Biomedicínske Centrum Slovakia
- École Polytechnique Fédérale de Lausanne EPFL Switzerland
Male, QH301-705.5, Adipose Tissue, White, Adipocytes, White, Peroxisome Proliferator-Activated Receptors, Smad Proteins, Bone Morphogenetic Protein 4, Rosiglitazone, Mice, Adipose Tissue, Brown, Cyclic AMP, Animals, Humans, Biology (General), Cell Line, Transformed, Adipogenesis, Cell Differentiation, Mesenchymal Stem Cells, Sterol Esterase, Mice, Inbred C57BL, Adipocytes, Brown, Diabetes Mellitus, Type 2, Gene Expression Regulation, Thiazolidinediones, Insulin Resistance, Signal Transduction
Male, QH301-705.5, Adipose Tissue, White, Adipocytes, White, Peroxisome Proliferator-Activated Receptors, Smad Proteins, Bone Morphogenetic Protein 4, Rosiglitazone, Mice, Adipose Tissue, Brown, Cyclic AMP, Animals, Humans, Biology (General), Cell Line, Transformed, Adipogenesis, Cell Differentiation, Mesenchymal Stem Cells, Sterol Esterase, Mice, Inbred C57BL, Adipocytes, Brown, Diabetes Mellitus, Type 2, Gene Expression Regulation, Thiazolidinediones, Insulin Resistance, Signal Transduction
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