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Natural Evolution of Broadly Neutralizing Antibodies

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2015 English Publisher:Elsevier BVJournal:Cell, volume 161, pages 427-428 (issn: 0092-8674,

Authors: Galit Alter; Dan H. Barouch; Dan H. Barouch;

doi: 10.1016/j.cell.2015.04.007

pmid: 25910199

pmc: PMC4426205

Natural Evolution of Broadly Neutralizing Antibodies

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Abstract

Wu et al. couple next-generation sequencing with structural analysis to illuminate the key processes that enable the natural evolution and selection of broadly neutralizing antibodies to HIV-1, providing a potential roadmap for the development of HIV-1 vaccine strategies to accelerate the induction of protective antibodies.

Related Organizations

Massachusetts Institute of Technology
United States
Ragon Institute of MGH, MIT and Harvard
United States
Beth Israel Deaconess Medical Center
United States

Keywords

Evolution, Molecular, B-Lymphocytes, Biochemistry, Genetics and Molecular Biology(all), HIV-1, Humans, HIV Infections, Antibodies, Neutralizing

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	5
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average