Neurogenesis in the Striatum of the Adult Human Brain
Copyright policy )Neurogenesis in the Striatum of the Adult Human Brain
In most mammals, neurons are added throughout life in the hippocampus and olfactory bulb. One area where neuroblasts that give rise to adult-born neurons are generated is the lateral ventricle wall of the brain. We show, using histological and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, which is adjacent to this neurogenic niche. The neuronal turnover in the striatum appears restricted to interneurons, and postnatally generated striatal neurons are preferentially depleted in patients with Huntington's disease. Our findings demonstrate a unique pattern of neurogenesis in the adult human brain.
Adult, brain, Neurogenesis, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], Biophysics, 610, [MATH.MATH-DS] Mathematics [math]/Dynamical Systems [math.DS], [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Hippocampus, Models, Biological, Basal Ganglia, Striatum, Subatomär fysik, Mice, Interneurons, 616, Subatomic Physics, Animals, Humans, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, cell renewal, Neurons, Biochemistry, Genetics and Molecular Biology(all), Brain, Olfactory Bulb, Biofysik, Huntington Disease, bomb-peak
Adult, brain, Neurogenesis, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], Biophysics, 610, [MATH.MATH-DS] Mathematics [math]/Dynamical Systems [math.DS], [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Hippocampus, Models, Biological, Basal Ganglia, Striatum, Subatomär fysik, Mice, Interneurons, 616, Subatomic Physics, Animals, Humans, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, cell renewal, Neurons, Biochemistry, Genetics and Molecular Biology(all), Brain, Olfactory Bulb, Biofysik, Huntington Disease, bomb-peak
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