A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
Copyright policy )A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
Recently, a new regulatory circuitry has been identified in which RNAs can crosstalk with each other by competing for shared microRNAs. Such competing endogenous RNAs (ceRNAs) regulate the distribution of miRNA molecules on their targets and thereby impose an additional level of post-transcriptional regulation. Here we identify a muscle-specific long noncoding RNA, linc-MD1, which governs the time of muscle differentiation by acting as a ceRNA in mouse and human myoblasts. Downregulation or overexpression of linc-MD1 correlate with retardation or anticipation of the muscle differentiation program, respectively. We show that linc-MD1 "sponges" miR-133 and miR-133 [corrected] to regulate the expression of MAML1 and MEF2C, transcription factors that activate muscle-specific gene expression. Finally, we demonstrate that linc-MD1 exerts the same control over differentiation timing in human myoblasts, and that its levels are strongly reduced in Duchenne muscle cells. We conclude that the ceRNA network plays an important role in muscle differentiation.
Genetics and Molecular Biology (all), RNA Processing, 571, RNA, Untranslated, Molecular Sequence Data, Post-Transcriptional, MADS Domain Proteins, Muscle Development, Biochemistry, Article, Myoblasts, Mice, Animals, Humans, Developmental, Muscular Dystrophy, RNA Processing, Post-Transcriptional, Muscle, Skeletal, Settore BIO/10 - BIOCHIMICA, mir-135; long non-coding rna; dmd; cerna; mir-133; mirna; maml1; mef2c; lincrna; muscle differentiation; duchenne muscular dystrophy, Base Sequence, Biochemistry, Genetics and Molecular Biology(all), MEF2 Transcription Factors, Animals; Base Sequence; DNA-Binding Proteins; Humans; MADS Domain Proteins; MEF2 Transcription Factors; Mice; MicroRNAs; Molecular Sequence Data; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Myoblasts; Myogenic Regulatory Factors; Nuclear Proteins; RNA Processing, Post-Transcriptional; RNA, Long Noncoding; RNA, Untranslated; Transcription Factors; Gene Expression Regulation, Developmental; Muscle Development; Biochemistry, Genetics and Molecular Biology (all), Untranslated, Correction, Gene Expression Regulation, Developmental, Nuclear Proteins, Skeletal, Duchenne, DNA-Binding Proteins, Muscular Dystrophy, Duchenne, MicroRNAs, Gene Expression Regulation, Myogenic Regulatory Factors, Muscle, RNA, Long Noncoding, RNA, Long Noncoding, Transcription Factors
Genetics and Molecular Biology (all), RNA Processing, 571, RNA, Untranslated, Molecular Sequence Data, Post-Transcriptional, MADS Domain Proteins, Muscle Development, Biochemistry, Article, Myoblasts, Mice, Animals, Humans, Developmental, Muscular Dystrophy, RNA Processing, Post-Transcriptional, Muscle, Skeletal, Settore BIO/10 - BIOCHIMICA, mir-135; long non-coding rna; dmd; cerna; mir-133; mirna; maml1; mef2c; lincrna; muscle differentiation; duchenne muscular dystrophy, Base Sequence, Biochemistry, Genetics and Molecular Biology(all), MEF2 Transcription Factors, Animals; Base Sequence; DNA-Binding Proteins; Humans; MADS Domain Proteins; MEF2 Transcription Factors; Mice; MicroRNAs; Molecular Sequence Data; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Myoblasts; Myogenic Regulatory Factors; Nuclear Proteins; RNA Processing, Post-Transcriptional; RNA, Long Noncoding; RNA, Untranslated; Transcription Factors; Gene Expression Regulation, Developmental; Muscle Development; Biochemistry, Genetics and Molecular Biology (all), Untranslated, Correction, Gene Expression Regulation, Developmental, Nuclear Proteins, Skeletal, Duchenne, DNA-Binding Proteins, Muscular Dystrophy, Duchenne, MicroRNAs, Gene Expression Regulation, Myogenic Regulatory Factors, Muscle, RNA, Long Noncoding, RNA, Long Noncoding, Transcription Factors
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