Granzyme A, a Stealth Killer in the Mitochondrion
Copyright policy )Granzyme A, a Stealth Killer in the Mitochondrion
The induction of caspase-independent cell death by killer lymphocytes involves the serine protease granzyme A (GzmA). In this issue, Martinvalet et al. (2008) show that GzmA penetrates the mitochondrial matrix without perturbing normal mitochondrial functions. In the mitochondrial matrix, GzmA cleaves NDUFS3 (a component of the electron transport chain) leading to production of reactive oxygen species and ultimately to cell death.
- University of Geneva Switzerland
Membrane Potential, Mitochondrial, 570, Cell Death, Biochemistry, Genetics and Molecular Biology(all), T-Lymphocytes, NADH Dehydrogenase, Membrane Potential, Granzymes, Mitochondrial, Mitochondria, Protein Transport, Animals, Humans, Reactive Oxygen Species, T-Lymphocytes, Cytotoxic, ddc: ddc:570
Membrane Potential, Mitochondrial, 570, Cell Death, Biochemistry, Genetics and Molecular Biology(all), T-Lymphocytes, NADH Dehydrogenase, Membrane Potential, Granzymes, Mitochondrial, Mitochondria, Protein Transport, Animals, Humans, Reactive Oxygen Species, T-Lymphocytes, Cytotoxic, ddc: ddc:570
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