Sox2: Masterminding the Root of Cancer
Copyright policy )Sox2: Masterminding the Root of Cancer
The transcription factor Sox2 is a master regulator that maintains stemness in embryonic stem cells and neural stem cells. Using elegant lineage tracing strategies and genetic reporter mouse models, two studies (one of which is by Vanner and colleagues in this issue of Cancer Cell) now demonstrate that rare Sox2-expressing cells are the founding cancer stem cell population driving tumor initiation and therapy resistance.
- Nanyang Technological University Singapore
- Massachusetts Institute of Technology United States
- Nationl University of Singapore Singapore
- Whitehead Institute for Biomedical Research United States
- National University of Singapore Singapore
Cancer Research, SOXB1 Transcription Factors, Cell Biology, Oncology, Biomarkers, Tumor, Animals, Hedgehog Proteins, Cerebellar Neoplasms, Cell Proliferation, Medulloblastoma
Cancer Research, SOXB1 Transcription Factors, Cell Biology, Oncology, Biomarkers, Tumor, Animals, Hedgehog Proteins, Cerebellar Neoplasms, Cell Proliferation, Medulloblastoma
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