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IDH1, Histone Methylation, and So Forth

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2016 English Publisher:Elsevier BVJournal:Cancer Cell, volume 30, pages 192-194 (issn: 1535-6108, Copyright policy )
Authors: Virginie Penard-Lacronique; Olivier Bernard;

doi: 10.1016/j.ccell.2016.07.008 , 10.1016/j.ccell.2016.08.010

pmid: 27622339 , 27505668

IDH1, Histone Methylation, and So Forth

Abstract

IDH mutants cause aberrant DNA and histone methylation and contribute to hematological and neuronal malignancies. In this issue of Cancer Cell, Inoue et al. describe a potential specific effect of IDH1 mutations that reduces Atm expression via inhibition of H3K9 demethylases, which may represent a first step toward cellular transformation.

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Keywords

Histones, Neoplasms, Mutation, Humans, DNA Methylation, Methylation, Isocitrate Dehydrogenase

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 7
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Average
Average
Average
hybrid
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Cancer Research