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Recent publications have questioned the appropriateness of the chemiosmotic theory, a key tenet of modern bioenergetics originally described by Mitchell and since widely improved upon and applied. In one of them, application of Gauss' law to a model charge distribution in mitochondria was argued to refute the possibility of ATP generation through H+ movement in the absence of a counterion, whereas a different author advocated, for other reasons, the impossibility of chemiosmosis and proposed that a novel energy-generation scheme (referred to as "murburn") relying on superoxide-catalyzed (or superoxide-promoted) ADP phosphorylation would operate instead. In this letter, those proposals are critically examined and found to be inconsistent with established experimental data and new theoretical calculations.
Osmosis, Bioenergetics, Hydrogen-Ion Concentration, Mitochondria, Proton-motive force, Adenosine Diphosphate, Chemiosmosis, Phosphorylation, Protons, Energy Metabolism, Gauss’s law
Osmosis, Bioenergetics, Hydrogen-Ion Concentration, Mitochondria, Proton-motive force, Adenosine Diphosphate, Chemiosmosis, Phosphorylation, Protons, Energy Metabolism, Gauss’s law
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| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
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