Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles
Copyright policy )Design, synthesis and antiproliferative activity of novel aminosubstituted benzothiopyranoisoindoles
The synthesis of a number of new benzothiopyrano[4,3,2-cd]isoindole aminoderivatives designed as structural analogues of the key metabolite of the anticancer agent Ledacrine (nitracrine) and their in vitro cytotoxic activity evaluation against HCT-116, MES-SA, and MES-SA/Dx cancer cell lines is reported. The majority of the derivatives possessed noticeable cytotoxicity in a low μM range indicating an interesting structure-activity relationship.
Indoles, Molecular Structure, Antineoplastic Agents, Inhibitory Concentration 50, Structure-Activity Relationship, Cell Line, Tumor, Drug Design, Humans, Nitracrine, Sulfhydryl Compounds, Amines, Cell Proliferation, Pyrans
Indoles, Molecular Structure, Antineoplastic Agents, Inhibitory Concentration 50, Structure-Activity Relationship, Cell Line, Tumor, Drug Design, Humans, Nitracrine, Sulfhydryl Compounds, Amines, Cell Proliferation, Pyrans
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