Synthesis and biological evaluation of PEG-tirofiban conjugates
Copyright policy )Synthesis and biological evaluation of PEG-tirofiban conjugates
We have conjugated tirofiban, an antagonist of the GPIIb/IIIa integrin receptor, to PEG, and shown that these polymers effectively inhibit platelet aggregation. This inhibition decreased with the size of the polymer. Our goal was to develop new cryoprotective agents to store frozen platelets. Surprisingly, tirofiban-conjugated PEG did not exhibit any protection.
Molecular Structure, Platelet Aggregation, Polymers, Platelet Glycoprotein GPIIb-IIIa Complex, Polyethylene Glycols, Mediator Complex Subunit 1, Structure-Activity Relationship, Cryoprotective Agents, Tirofiban, Freezing, Humans, Tyrosine, Collagen, Platelet Aggregation Inhibitors, Transcription Factors
Molecular Structure, Platelet Aggregation, Polymers, Platelet Glycoprotein GPIIb-IIIa Complex, Polyethylene Glycols, Mediator Complex Subunit 1, Structure-Activity Relationship, Cryoprotective Agents, Tirofiban, Freezing, Humans, Tyrosine, Collagen, Platelet Aggregation Inhibitors, Transcription Factors
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