Genomic basis of delayed reward discounting
Copyright policy )Genomic basis of delayed reward discounting
Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity, reflecting how rapidly a reward loses value based on its temporal distance. In humans, more impulsive DRD is associated with susceptibility to a number of psychiatric diseases (e.g., addiction, ADHD), health outcomes (e.g., obesity), and lifetime outcomes (e.g., educational attainment). Although the determinants of DRD are both genetic and environmental, this review focuses on its genetic basis. Both rodent studies using inbred strains and human twin studies indicate that DRD is moderately heritable, a conclusion that was further supported by a recent human genome-wide association study (GWAS) that used single nucleotide polymorphisms (SNP) to estimate heritability. The GWAS of DRD also identified genetic correlations with psychiatric diagnoses, health outcomes, and measures of cognitive performance. Future research priorities include rodent studies probing putative genetic mechanisms of DRD and human GWASs using larger samples and non-European cohorts. Continuing to characterize genomic influences on DRD has the potential to yield important biological insights with implications for a variety of medically and socially important outcomes.
- University of California, San Diego United States
- McMaster University Canada
- St. Joseph’s Healthcare Hamilton Canada
- St. Joseph's Healthcare Hamilton
- University of Guelph Canada
Behavioral Science & Comparative Psychology (science-metrix), Economics, Biological Psychology, 3105 Genetics (for-2020), Impulsive Behavior (mesh), Pharmacology & Pharmacy (science-metrix), Brain Disorders (rcdc), Behavioral (mesh), Psychology, Addictive, Animals (mesh), 3109 Zoology (for-2020), Pharmacology & Pharmacy, Delayed reward discounting, Cognitive and computational psychology, Humans (mesh), 3 Good Health and Well Being (sdg), 52 Psychology (for-2020), Economics, Behavioral, Single Nucleotide, Pharmacology and Pharmaceutical Sciences, Genomics, Biological Sciences, Mental Illness, Mental Health, Delay Discounting, 5202 Biological Psychology (for-2020), Cognitive Sciences, Genome-Wide Association Study (mesh), Behavioral and Social Science (rcdc), Mental Health (rcdc), Mental Illness (rcdc), Single Nucleotide (mesh), Impulsivity, 0801 Artificial Intelligence and Image Processing (for), Social and personality psychology, Artificial Intelligence and Image Processing, 610, 5204 Cognitive and computational psychology (for-2020), Behavioral Science & Comparative Psychology, Basic Behavioral and Social Science, Polymorphism, Single Nucleotide, 5205 Social and personality psychology (for-2020), Reward, Behavioral and Social Science, 616, Genetics, Animals, Humans, Polymorphism, Behavioral, Behavior, 31 Biological Sciences (for-2020), 1115 Pharmacology and Pharmaceutical Sciences (for), Genetics (rcdc), Human Genome, Delay Discounting (mesh), Reward (mesh), Human Genome (rcdc), Brain Disorders, Mental health (hrcs-hc), Behavior, Addictive, Good Health and Well Being, Genomics (mesh), Impulsive Behavior, 1702 Cognitive Sciences (for), 1701 Psychology (for), 3214 Pharmacology and pharmaceutical sciences (for-2020), Basic Behavioral and Social Science (rcdc), Zoology, Addictive (mesh), Genome-Wide Association Study
Behavioral Science & Comparative Psychology (science-metrix), Economics, Biological Psychology, 3105 Genetics (for-2020), Impulsive Behavior (mesh), Pharmacology & Pharmacy (science-metrix), Brain Disorders (rcdc), Behavioral (mesh), Psychology, Addictive, Animals (mesh), 3109 Zoology (for-2020), Pharmacology & Pharmacy, Delayed reward discounting, Cognitive and computational psychology, Humans (mesh), 3 Good Health and Well Being (sdg), 52 Psychology (for-2020), Economics, Behavioral, Single Nucleotide, Pharmacology and Pharmaceutical Sciences, Genomics, Biological Sciences, Mental Illness, Mental Health, Delay Discounting, 5202 Biological Psychology (for-2020), Cognitive Sciences, Genome-Wide Association Study (mesh), Behavioral and Social Science (rcdc), Mental Health (rcdc), Mental Illness (rcdc), Single Nucleotide (mesh), Impulsivity, 0801 Artificial Intelligence and Image Processing (for), Social and personality psychology, Artificial Intelligence and Image Processing, 610, 5204 Cognitive and computational psychology (for-2020), Behavioral Science & Comparative Psychology, Basic Behavioral and Social Science, Polymorphism, Single Nucleotide, 5205 Social and personality psychology (for-2020), Reward, Behavioral and Social Science, 616, Genetics, Animals, Humans, Polymorphism, Behavioral, Behavior, 31 Biological Sciences (for-2020), 1115 Pharmacology and Pharmaceutical Sciences (for), Genetics (rcdc), Human Genome, Delay Discounting (mesh), Reward (mesh), Human Genome (rcdc), Brain Disorders, Mental health (hrcs-hc), Behavior, Addictive, Good Health and Well Being, Genomics (mesh), Impulsive Behavior, 1702 Cognitive Sciences (for), 1701 Psychology (for), 3214 Pharmacology and pharmaceutical sciences (for-2020), Basic Behavioral and Social Science (rcdc), Zoology, Addictive (mesh), Genome-Wide Association Study
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