Psychobiology of the placebo response

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2006 English Publisher:Elsevier BVJournal:Autonomic Neuroscience, volume 125, pages 94-99 (issn: 1566-0702,

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Authors: Sibylle, Klosterhalfen; Paul, Enck;

doi: 10.1016/j.autneu.2006.01.015

pmid: 16515893

Psychobiology of the placebo response

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Abstract

The nature and determinants of the placebo response are widely unknown and are discussed controversially. This review presents a unifying concept for the understanding of the placebo response in clinical trials and practice based on three components: "Regression to the mean", "Pavlovian conditioning", and "Signal detection theory", and discusses the respective literature in light of experimental and clinical findings from psychology, psychiatry, neurology, and gastroenterology, with specific emphasis on "brain imaging" of the placebo response.

Related Organizations

Institut für Medizinische Psychologie
Germany
Universitätsklinikum Tübingen
Germany

Keywords

Brain Mapping, Gastrointestinal Diseases, Conditioning, Classical, Animals, Humans, Placebo Effect, Randomized Controlled Trials as Topic

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