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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Advanced Powder Tech...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Advanced Powder Technology
Article . 2012 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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Compactibility improvement of metformin hydrochloride by crystallization technique

Authors: Bhavesh S. Barot; Punit B. Parejiya; Tushar M. Patel; Rajesh K. Parikh; Mukesh C. Gohel;

Compactibility improvement of metformin hydrochloride by crystallization technique

Abstract

Abstract The objectives of the present study were to address the issues of poor flow and inadequate compressibility of metformin HCl by adopting particle engineering technique. Metformin HCl was crystallized in the presence of polyvinylpyrrolidone (PVP K30). A 3 2 full factorial design (FFD) was employed for optimization of the processing parameters. Percentage PVP K30 in solution ( X 1 ) and crystallization time ( X 2 ) were chosen as the independent variables. Percentage yield ( Y 1 ), Carr’s index ( Y 2 ) and tensile strength of compacts ( Y 3 ) were selected as dependent variables. Mathematical models were evolved and contour plots were drawn. Metformin HCl particles crystallized in the presence of 2% PVP K30 with crystallization time of four hours (CryMet), showed impressive improvement in flow property, compressibility as well as compactibility as compared to untreated metformin HCl (XMet). The derived compaction parameters ‘ a ’, ‘1 /b ’ and ‘ P y ’, obtained using Kawakita and Heckel equations were 0.369, 15.34 and 198.54 MPa for XMet; and 0.249, 11.05 and 143.33 MPa for CryMet respectively. Compressibility evaluation of the samples revealed poor compressibility of XMet while CryMet was directly compressible. DSC and FTIR experiments showed that CryMet particles did not undergo chemical modifications during crystallization.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
29
Top 10%
Top 10%
Top 10%
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