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Isoniazid metabolism and hepatotoxicity

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Sep 2016 English Publisher:Elsevier BVJournal:Acta Pharmaceutica Sinica B, volume 6, pages 384-392 (issn: 2211-3835, Copyright policy )Funded by:NIH | Control of developmental ..., NIH | Short- or long-term impac..., NIH | Mechanisms of adverse eff...
Authors: Xiaochao Ma; Xiao-bo Zhong; Komal Pradhan; Pengcheng Wang;

doi: 10.1016/j.apsb.2016.07.014

pmid: 27709007

pmc: PMC5045547

Isoniazid metabolism and hepatotoxicity

Abstract

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.

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Keywords

Hepatotoxicity, RM1-950, Review, Metabolism, Isoniazid, Therapeutics. Pharmacology, Anti-tuberculosis, N-Acetyltransferase 2, Amidase

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 201
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
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    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
201
Top 1%
Top 10%
Top 1%
Green
gold
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