Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety
Copyright policy )Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety
The objective of this research was to determine the dose-response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX(®) (PGX(®)), [(α-D-glucurono-α-manno-β-D-manno-β-D-gluco), (α-Lgulurono-β-D mannurono), (β-D-gluco-β-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n = 10), aged between 20.3 and 29.2 years, consumed PGX(®), in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX(®) doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7, P = 0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control.
- University of British Columbia Canada
- Curtin University Australia
- University of Sydney Australia
- University of British Colombia Canada
- Murdoch University Australia
Adult, Blood Glucose, Dietary Fiber, Alginates, satiety, 610, Appetite, Satiation, Fibre, Young Adult, Humans, Psychology(all), Nutrition and Dietetics, Dose-Response Relationship, Drug, Polysaccharides, Bacterial, dose, Postprandial Period, Satiety, Drug Combinations, Dose, fibre, Area Under Curve
Adult, Blood Glucose, Dietary Fiber, Alginates, satiety, 610, Appetite, Satiation, Fibre, Young Adult, Humans, Psychology(all), Nutrition and Dietetics, Dose-Response Relationship, Drug, Polysaccharides, Bacterial, dose, Postprandial Period, Satiety, Drug Combinations, Dose, fibre, Area Under Curve
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