With the aim of derive a quasi-monomiality formulation in the context of discrete hypercomplex variables, one will amalgamate through a Clifford-algebraic structure of signature $(0,n)$ the umbral calculus framework with Lie-algebraic symmetries. The exponential generating function ({\bf EGF}) carrying the {\it continuum} Dirac operator $D=\sum_{j=1}^n\e_j\partial_{x_j}$ together with the Lie-algebraic representation of raising and lowering operators acting on the lattice $h\BZ^n$ is used to derive the corresponding hypercomplex polynomials of discrete variable as Appell sets with membership on the space Clifford-vector-valued polynomials. Some particular examples concerning this construction such as the hypercomplex versions of falling factorials and the Poisson-Charlier polynomials are introduced. Certain applications from the view of interpolation theory and integral transforms are also discussed.

24 pages. 1 figure. v2: a major revision, including numerous improvements throughout the paper was done