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Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

Authors: Len C. Harrison; Judith M. Podskalny; Emmanuel Van Obberghen; Jeffery S. Flier; C. Grunfeld; George L. King; M Kasuga; +5 Authors

Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

Abstract

Publisher Summary Insulin exerts a wide spectrum of effects at the cellular level. These include effects at the membrane level, for example, the stimulation of glucose and amino acid uptake; effects on both membrane and cytoplasmic enzymes; and effects on protein synthesis, DNA synthesis, cell growth, and differentiation. This is the reason why unraveling the mechanism of insulin action has been difficult. This chapter describes insulin receptors, receptor antibodies, and the mechanism of insulin action. In addition, the effects of insulin vary both in time course and dose–response. Some effects of insulin, such as the stimulation of glucose transport, occur within seconds after hormone exposure, whereas others, such as the stimulation of DNA synthesis, require hours; effects on most cytoplasmic enzymes lie somewhere between these two extremes. It is well known that insulin stimulates glucose transport, and this effect persists in membrane vesicles even after the cell is broken. Several new probes have become available that have shed some light on the problem of insulin action. These include cultured cell systems, which are highly responsive to insulin; new methods for studying receptor structure; mutant cell lines that possess defects in either the insulin receptor or pathways of insulin action; and antibodies to the insulin receptor that block insulin binding and mimic insulin action.

Related Organizations
Keywords

Adult, Male, Adolescent, Macromolecular Substances, Protein Conformation, Insulin Antibodies, Receptors, Cell Surface, Receptors, Somatomedin, Antigen-Antibody Complex, Middle Aged, Receptor, Insulin, Models, Structural, Somatomedins, Animals, Humans, Insulin, Female, Child, Peptides

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    190
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
190
Top 10%
Top 1%
Top 1%
gold
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