Synthetic methods for phosphoryl compounds are described. The methods cover 75 classes of compounds. These include dialkyl/diaryl phosphoryl substances of general structure: ROP(O)Cl2, ArOP(O)Cl2, ROP(O)F2, ArOP(O)F2, ROP(O)(NR2)2, ROP(O)(NHNHR)2, ROP(O)(NCO)2, ROP(O)(NCS)2, ROP(O)(OH)2, ROP(O)(SR)2, RO(RS)P(O)Cl, RO(R2N)P(O)Cl, RS(R2N)P(O)Cl, (RS)2P(O)Cl, RO(RS)P(O)F, RO(R2N)P(O)F, (RO)2P(O)H, RO(R′O)P(O)H, (ArO)2P(O)H, (RO)2P(O)X (X = F, Cl, Br, I, and CN), (ArO)2P(O)Cl, (RO)2P(O)C(O)X (X = OR, SR, NR2, and NHOR), (RO)2P(O)C(S)SR, (RO)2P(O)OX (X = H, OR, R, NCR2 and CRCR2), RO(R′O)P(O)OH, (ArO)2P(O)OR, (ArO)3PO, (RO)2P(O)N3, (RO)2P(O)NR2, (RO)2P(O)NHAr, (ArO)2P(O)NR2, (RO)2P(O)N(Me)P(X)R2 (X = O or S), (RO)2P(O)N(Me)COR, (RO)2P(O)N(Cl)Ar, (RO)2P(O)NX2 (X = Cl or Br), (RO)2P(O)NHOR (R = H or alkyl), (RO)2P(O)NHNH2, (RO)2P(O)NCO, (RO)2P(O)NCS, (RO)2P(O)NSO, (RO)2P(O)NHSO2NHP(O)(OR)2, (RO)2P(O)NCHR, (RO)2P(O)NC(NR2)2, (RO)2P(O)SR (R = H, alkyl/aryl, SR, and OR), (RO)2P(O)S(O)OR, (RO)2P(O)XP(O)(OR)2 (X = O, S, SS, and SO), RNHP(O)Cl2, R2NP(O)X2 (X = Cl and F), (R2N)2P(O)X (X = H, Cl, F, and N3), (R2N)2P(O)OP(O)(NR2)2, (RNH)3PO and (R2N)3PO.