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International Journal of Pharmaceutics
Article . 1989 . Peer-reviewed
License: Elsevier TDM
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International Journal of Pharmaceutics
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Lipophilicity of guanine derivatives

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1989 English Publisher:Elsevier BVJournal:International Journal of Pharmaceutics, volume 57, pages 229-234 (issn: 0378-5173, Copyright policy )
Authors: Albin Kristl; J. Kobe; F. Kozjek; Aleš Mrhar;

doi: 10.1016/0378-5173(89)90212-3

Lipophilicity of guanine derivatives

Abstract

Abstract Lipid-water partition coefficients for acyclovir and deoxyacyclovir were determined by partition experiment. The ionisation constants and the real partition coefficients were calculated by linear regression methods. The contradiction in lipophilicity and water solubility for acyclovir and deoxyacyclovir as determined previously (Kozjek et al., 1988) was explained by these data and with the aid of differential scanning calorimetry.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
10
Average
Top 10%
Average
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