Some of the critical values have been selected from the various criteria just reviewed and are listed below. Acute oral toxicity. Twenty to 70 mg/kg, aldrin or dieldrin, 12 species. The estimated lethal dose for man is approximately 5 g. Mortality on repeated doses. (a) Short-term: quail, dog, turkey, mouse, <25 ppm; cat and pheasant, <100 ppm; cow, sheep, and rabbit, <165 ppm; rat, <300 ppm. (b) Short-term or chronic: quail, 0.5 ppm of aldrin, 1 ppm of dieldrin; monkey, 5 ppm of dieldrin; mouse, 10 ppm of aldrin and dieldrin; dog, 10 ppm of aldrin, 25 ppm of dieldrin; turkey, 12.5 ppm of aldrin; rabbit, 80 ppm of aldrin, 20 ppm of dieldrin; rat, 100–150 ppm of aldrin or dieldrin. Body weight. No change at 2 ppm or less. Changes: monkey, 2.5 ppm of dieldrin; male turkey, 3 ppm of aldrin; sheep and cow, 7 ppm of aldrin in hay; dog (pup), 10–25 ppm of aldrin; rat, 300 ppm of aldrin or dieldrin. Food consumption, hematology, urine analyses. Not sensitive. Liver weight: body weight increase. Rat, 0.5, 2.5 ppm; dog, 3 ppm of aldrin, 1 ppm of dieldrin. Pathology. Rat, 2 ppm of aldrin, 0.5 ppm of dieldrin; dog, 3 ppm of aldrin, 8 ppm of dieldrin; mouse, 10 ppm of aldrin or dieldrin. Reproduction. Rat, fewer pregnancies, greater mortality of pups, 12.5 ppm of aldrin, 2.5 ppm of dieldrin; dog, greater mortality of pups, 8 ppm of aldrin, 25 ppm of dieldrin; sheep, greater mortality of lambs, 25 ppm of dieldrin; quail, some changes at 1–10 ppm of dieldrin; pheasant, 25 ppm of dieldrin. Human. Typical diets in England and in the United States are estimated to contain 0.001–0.002 ppm of dieldrin. Dieldrin concentrations in human fat probably average about 0.2 ppm. Blood concentrations exceeded 20 μg per 100 ml in exposed patients showing signs of intoxication.