Abstract There is no substitute for periodontal treatment when the integrity of the periodontal tissues is disturbed or destroyed by the formation of calculus, or by the occurrence of gingival infections from local or systemic factors, or when alveolar bone loss occurs. Periodontal treatment is not always available or possible to a large portion of our population. Institutionalized patients with brain damage and patients with neuromuscular disorders (muscular dystrophy, multiple sclerosis, and cerebral palsy), as well as young and old patients with chronic debilitating disease, often make periodontal treatment impossible. The use of Clorpactin mouthwash for such patients is highly recommended, since it will control secondary infection, debride necrotic tissue, arrest gingival bleeding, and deodorize the mouth without any untoward results. Clorpactin also may be used as an adjunct in periodontal treatment.