Cymbopogon citratus, commonly known as lemongrass - a herb in Asian cuisine, is well known for its medicinal properties since ancient period and have been reported in ancient Indian Ayurvedic Medicine for relieving cough and nasal congestion. Since the early 1980s, an alarming problem of groundwater arsenic (As) contamination has devastated eastern Indian regions. Arsenic is a known human carcinogen and an environmental pollutant known to cause adverse health effects such as liver injury, neurotoxicity, increase the risk of cancers of skin, lung, bladder and liver. DNA damage and genetic instability induced by the inorganic arsenicals present in water are thought to be prerequisites for the initiation of carcinogenesis. Many natural herbs, which are consumed through our daily diet, possess excellent cancer chemopreventive properties. The present study was conducted to examine the anticlastogenic action of lemongrass extract against the As-induced chromosomal aberrations. Our results demonstrate that lemongrass extract particularly Citral (60 mg/kg/b.w) is effective in counteracting the clastogenicity, of the most potent form of As, sodium arsenite in mice. These results suggest that the use of lemongrass in diet may give an effective protection against the health crisis generated by As.