
pmid: 20635203
We propose a Bayesian approach for estimating the hazard functions under the constraint of a monotone hazard ratio. We construct a model for the monotone hazard ratio utilizing the Cox's proportional hazards model with a monotone time-dependent coefficient. To reduce computational complexity, we use a signed gamma process prior for the time-dependent coefficient and the Bayesian bootstrap prior for the baseline hazard function. We develop an efficient MCMC algorithm and illustrate the proposed method on simulated and real data sets.
Ovarian Neoplasms, Stochastic Processes, Leukemia, Censored data models, Mercaptopurine, proportional hazards model, Bayesian inference, Estimation in survival analysis and censored data, Bayes Theorem, Markov Chains, Applications of statistics to biology and medical sciences; meta analysis, monotone hazard ratio, censoring, order restriction, Humans, Computer Simulation, Female, Bayesian bootstrap, Monte Carlo Method, Algorithms, Proportional Hazards Models
Ovarian Neoplasms, Stochastic Processes, Leukemia, Censored data models, Mercaptopurine, proportional hazards model, Bayesian inference, Estimation in survival analysis and censored data, Bayes Theorem, Markov Chains, Applications of statistics to biology and medical sciences; meta analysis, monotone hazard ratio, censoring, order restriction, Humans, Computer Simulation, Female, Bayesian bootstrap, Monte Carlo Method, Algorithms, Proportional Hazards Models
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