Hyperserotonemia in Adults with Autistic Disorder
Copyright policy )Hyperserotonemia in Adults with Autistic Disorder
Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7 +/- 37.4 ng/microL) was significantly higher than the control sample (59.2 +/- 16.2 ng/microL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects.
- University of Queensland Australia
- University of Queensland Australia
- Ruđer Bošković Institute Croatia
- Croatian Institute of Transfusion Medicine Croatia
- University of Zagreb Croatia
Blood Serotonin, Adult, Blood Platelets, Male, Serotonin, Adolescent, Autism, Statistics as Topic, 150, Platelet serotonin level, Transporter, Speech Disorders, Hyperserotonemia, Platelet Serotonin Levels, Reference Values, Intellectual Disability, Humans, Language Development Disorders, Autistic Disorder, Children, 3204 Developmental and Educational Psychology, Verbal communication, Verbal Behavior, Speech development, Childhood, Relatives, autism; hyperserotonemia; platelet serotonin level; speech development; verbal communication, Female, Model
Blood Serotonin, Adult, Blood Platelets, Male, Serotonin, Adolescent, Autism, Statistics as Topic, 150, Platelet serotonin level, Transporter, Speech Disorders, Hyperserotonemia, Platelet Serotonin Levels, Reference Values, Intellectual Disability, Humans, Language Development Disorders, Autistic Disorder, Children, 3204 Developmental and Educational Psychology, Verbal communication, Verbal Behavior, Speech development, Childhood, Relatives, autism; hyperserotonemia; platelet serotonin level; speech development; verbal communication, Female, Model
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