Migratory potential of transplantable neural tumor cell lines
Copyright policy )Migratory potential of transplantable neural tumor cell lines
Experimentally induced primitive neuroectodermal tumor (PNET) cell lines were transplanted into neonatal and adult rat brain and examined neuropathologically for their tumorigenic potential. Both cell lines showed a striking migratory behavior in both neonatal and adult brain. Migration of tumor cells was found in host brain parenchyma, along white matter tracts and associated with CSF pathways. These neural tumor cell lines provide a valuable tool for the development of strategies against strongly migrating neural tumors.
- University of Bonn Germany
- Institut für Neuropathologie Germany
- RWTH Aachen University Germany
Brain Neoplasms, Cell Movement, Tumor Cells, Cultured, Animals, Matrix Metalloproteinase 2, Transplants, Immunohistochemistry, Rats
Brain Neoplasms, Cell Movement, Tumor Cells, Cultured, Animals, Matrix Metalloproteinase 2, Transplants, Immunohistochemistry, Rats
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