The present study compared the effects of discrete trial instruction (DTI) and mand training on the acquisition of independent requests in 6 children with autism. Two multiple-probe designs across participants were conducted with 3 participants receiving mand training followed by DTI and the other 3 receiving DTI followed by mand training. Eye contact and challenging behaviors were also assessed across conditions. Results indicate that 5 of 6 participants made more independent requests and acquired requesting faster in the mand training condition, had slightly better eye contact in the DTI condition, and fewer challenging behaviors in the mand training condition. Overall, the results indicate that mand training is a more efficient method for teaching children with autism to make requests.