Jordanian adolescents feel uncomfortable discussing personal health practices including drugs, alcohol, tobacco use, and cancer self-examination. Both Islam and Christianity prohibit illicit drug use. Jordanian society considers drinking alcohol to be a violation of religious tenets and social customs. Some adults erroneously believe that avoiding discussion of drug or alcohol use prevents youth from risky behavior. Asking adolescents about their tobacco use practices is difficult as underage smoking is deemed unacceptable behavior. Because smoking is considered physically harmful, it is forbidden in Islam and Christianity. Cultural norms affect discussion about sexual behaviors, human sexuality, and reproductive health concerns. As a consequence, there is limited focus on sexual function, reproductive disorders, contraception, and sexual violence within institutional settings. Both Islam and Christianity encourage people to promote their health through preventive actions. Intervention studies are needed to identify the most effective methods to challenge and dispel misperceptions about the risks of cancers such as breast cancer. Interventions should focus on promoting understanding of cancer screening, and encouraging cancer screening decisions that are consistent with individual preferences and values. Researchers must adapt methods to honor cultural preferences and values. Religion can be used to encourage health-related behaviors. Furthermore, medical education should be a cornerstone for promoting health and adopting healthy behaviors.