The reproductive cycle of the common opossumDidelphis marsupialis Linnaeus, 1758, inhabiting an agricultural area in the Venezuelan Andes was studied by live-trapping for 18 months (from July 1998 to December 1999). Trap success was slightly higher in the less humid months. Most females captured breed during the least rainy period, with two different birth peaks: January-March and April-June, a minor reproductive event occurs from August to October. Reproductive activity ofD. marsupialis appears closely associated with precipitation.