We have presented in some detail the more common clinical syndromes produced by the ingestion of natural seafood toxins, and touched on those that could be of interest to the international traveler and to the sport fisherman. For the practicing allergist, knowledge of this wide array of clinical syndromes of toxicity is of paramount importance for the proper differential diagnosis of seafood allergy. In the majority of cases, the diagnosis is clinical, and therefore a careful history and physical exam are essential.