The crossability of Group Andigena haploids was investigated in this study. Groups Phureja, Stenotomum and Tuberosum haploids were crossed to Gp. Andigena haploids reciprocally to estimate the female and male fertility of the latter. The male fertility of Gp. Andigena haploids was reflected by the average seed set from crosses to Gps. Phureja Stenotomum and Tuberosum haploids (69, 43 and 21 seeds per fruit, respectively); female fertility was expressed when Gps. Phureja or Stenotomum served as the male, yielding 48 and 38 seeds per fruit, respectively. To contrast Gp. Andigena and Gp. Tuberosum haploid male fertility, they were crossed among and between themselves. As males, Gp. Andigena haploids gave three to four times the seed set of Gp. Tuberosum haploids. Pollen tube growth was analyzed in various Gp. Andigena haploid crosses to determine the site of cross failure. The results presented provide the basis for the first step in determining the potential of Gp. Andigena haploids in the development of diploid breeding stocks and the 2n gamete approach to potato improvement.