Effects of subinhibitory concentrations of nitroxoline on the surface properties ofEscherichia coli

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2000 English Publisher:Springer Science and Business Media LLCJournal:Folia Microbiologica, volume 45, pages 485-490 (issn: 0015-5632, eissn: 1874-9356,

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Authors: H, Latrache; P, Bourlioux; M, Karroua; H, Zahir; A, Hakkou;

doi: 10.1007/bf02818714

pmid: 11501411

Effects of subinhibitory concentrations of nitroxoline on the surface properties ofEscherichia coli

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Abstract

Nitroxoline (5-nitro-8-quinolinol; NIQ) at subinhibitory concentrations (sub-MIC) decreased the adherence of uropathogenic Escherichia coli to catheter surface and significantly enhanced cell surface hydrophobicity. The surface hydrophobicity increased in the presence of sub-MIC of NIQ and also in an excess of Mg2+. The effect of NIQ on the cell surface was not related to the bacteriostatic effect of this agent. The increase in nitrogen and decrease in phosphate content in the cell surface was found in the presence of NIQ. NIQ did not inhibit the expression of fimbriae.

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Keywords

Surface Properties, Cell Membrane, Nitroquinolines, In Vitro Techniques, Bacterial Adhesion, Microscopy, Electron, Urinary Tract Infections, Escherichia coli, Humans, Urinary Catheterization, Escherichia coli Infections

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