Histamine releasing action of calcium ionophore 985-I

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1988 Lithuania English Publisher:Springer Science and Business Media LLCJournal:Agents and Actions, volume 23, pages 161-164 (issn: 0065-4299, eissn: 1420-908X,

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Authors: Gushchin, Igor S.; Zebrev, Alexander I.; Voitenko, Valentina;

doi: 10.1007/bf02142528

pmid: 2455977

handle: 20.500.12512/48503

Histamine releasing action of calcium ionophore 985-I

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Abstract

The polyether antibiotic 985-I induced histamine release from rat and mouse mast cells and human basophils. Histamine release induced by low concentrations (10-50 microM) of the ionophore was a selective (noncytotoxic) process. It was energy and Ca2+-dependent and was potentiated by glucose. In this respect the mode of action of 985-I was similar to that of the Ca2+-ionophore A23187. On the other hand some pharmacological agents (phencarol, verapamil and amitriptyline) inhibited histamine secretion induced by 985-I but not A23187-induced histamine release. These data point to some differences between the mechanisms of action of 985-I and A23187.

Country

Lithuania

Related Organizations

Lithuanian University of Health Sciences
Lithuania

Keywords

Male, Ionophores, Rats, Inbred Strains, In Vitro Techniques, Histamine Release, Basophils, Rats, MEDLINE (PubMed), Mice, Imunologija., Mice, Inbred CBA, Animals, Humans, Straipsnis kitoje duomenų bazėje / Article in other database (S4), Mast Cells, Calcimycin, Medicina / Medicine (M001), Ethers

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