Stimulation of human neutrophil migration by aurothioglucose and thioglucose

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1993 English Publisher:Springer Science and Business Media LLCJournal:Agents and Actions, volume 38, pages C133-C135 (issn: 0065-4299, eissn: 1420-908X,

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Authors: J G, Elferink; B M, de Koster;

doi: 10.1007/bf01991162

pmid: 8100382

Stimulation of human neutrophil migration by aurothioglucose and thioglucose

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Abstract

Migration of human neutrophils was enhanced by aurothioglucose in a concentration-dependent manner. Migration was especially pronounced when the drug was present in the lower compartment of the Boyden chamber, suggesting that the enhancement of migration was chemotactic rather than chemokinetic. Thioglucose followed the same pattern of stimulation as the related gold compound, but the enhancement at the maximally stimulating concentration was less; at higher concentrations thioglucose inhibited random migration.

Related Organizations

Leiden University
Netherlands

Keywords

Aurothioglucose, Methylene Blue, Chemotaxis, Leukocyte, Glucose, Guanylate Cyclase, Neutrophils, Aminoquinolines, Humans, Drug Synergism, SRS-A

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