Hydrolysis and determination of meprobamate

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1983 English Publisher:Springer Science and Business Media LLCJournal:Pharmaceutisch Weekblad Scientific Edition, volume 5, pages 186-188 (issn: 0167-6555, eissn: 1573-739X,

Copyright policy )

Authors: S M, Dreijer-van der Glas; H A, Dingjan;

doi: 10.1007/bf01961480

pmid: 6622215

Hydrolysis and determination of meprobamate

- Summary
- Subjects
- Metrics

Abstract

Most pharmacopoeial methods for meprobamate are based on acid hydrolysis, followed by determination of the ammonia formed. In order to find optimum conditions the hydrolysis was studied with the aid of TLC. Various types and concentrations of acid were tested. Refluxing with 25% (wt/vol) HCl for two hours proved to be sufficient to achieve complete hydrolysis (99.4 +/- 1%). This method is less time-consuming than that of the European Pharmacopoeia and the hydrolysate does not turn brown as is the case with high concentrations of H2SO4.

Related Organizations

Leiden University
Netherlands

Keywords

Time Factors, Benzaldehydes, Hydrolysis, Meprobamate, Hydrogen-Ion Concentration, Mass Spectrometry

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	4
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average