The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid fromSimarouba amara
Copyright policy )The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid fromSimarouba amara
An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2'-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2'-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.
ANTILEUCEMIQUE, SIMAROUBACAEA, DEHYDROGLAUCARUBINONE, Plants, Medicinal, SIMAROUBA AMARA, Glaucarubin, 610, QUASSINOIDE, Neoplasms, Experimental, Antineoplastic Agents, Phytogenic, Structure-Activity Relationship, 18, 2' ACETYLGLAUCARUBINE-13, Phytotherapy
ANTILEUCEMIQUE, SIMAROUBACAEA, DEHYDROGLAUCARUBINONE, Plants, Medicinal, SIMAROUBA AMARA, Glaucarubin, 610, QUASSINOIDE, Neoplasms, Experimental, Antineoplastic Agents, Phytogenic, Structure-Activity Relationship, 18, 2' ACETYLGLAUCARUBINE-13, Phytotherapy
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