Brain quinolinic acid in Alzheimer's dementia
Copyright policy )Brain quinolinic acid in Alzheimer's dementia
Quinolinic acid (QA) content was measured in postmortem frontal and temporal cortex, putamen and cerebellum obtained from patients with senile dementia of Alzheimer type (SDAT), Huntington's disease (HD) and controls, using a gas chromatography/mass spectrometry method. There were no significant group differences in QA content of any of the regions examined. The data do not support the hypothesis that an accumulation of QA plays a role in neuronal degeneration occurring in the frontal and temporal cortex, putamen and cerebellum of patients with SDAT.
- University of Vienna Austria
- Imperial College Healthcare NHS Trust United Kingdom
- University of Würzburg Germany
- Queen Charlotte's and Chelsea Hospital United Kingdom
Adult, Male, Pyridines, Putamen, Brain, Quinolinic Acid, Temporal Lobe, Frontal Lobe, Quinolinic Acids, Huntington Disease, Alzheimer Disease, Cerebellum, Humans, Female, Aged
Adult, Male, Pyridines, Putamen, Brain, Quinolinic Acid, Temporal Lobe, Frontal Lobe, Quinolinic Acids, Huntington Disease, Alzheimer Disease, Cerebellum, Humans, Female, Aged
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