Sequence and genomic organization of a rabbit hemorrhagic disease virus isolated from a wild rabbit

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1995 France English Publisher:Springer Science and Business Media LLCJournal:Virus Genes, volume 9, pages 121-132 (issn: 0920-8569, eissn: 1572-994X,

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Authors: Rasschaert, Denis; Huguet, Stephanie; Madelaine, M.F.; Vautherot, Jean-François;

doi: 10.1007/bf01702655

pmid: 7732658

Sequence and genomic organization of a rabbit hemorrhagic disease virus isolated from a wild rabbit

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Abstract

Rabbit hemorrhagic disease virus (RHDV) is a member of the caliciviridae family. The nucleotidic sequence of a full-length cDNA of one RHDV isolate (RHDV-SD) is reported. The genome is 7437 bases long and includes two ORFs, ORF1 (7034 b) and ORF2 (353 b), coding for the polyprotein and the Vp12, respectively. The coding sequence for the second structural protein (the capsid protein, Vp60) is located at the 3' end of ORF1. Comparison of RHDV-SD with the German RHDV isolated revealed 470 nucleotide substitutions (96% homology). The deduced amino acid sequences of the two isolates are closely related (98% identity), and no hypervariable region could be identified either in the structural or nonstructural proteins.

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France

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Keywords

DNA, Complementary, Base Sequence, Sequence Homology, Amino Acid, Hemorrhagic Disease Virus, Rabbit, [SDV]Life Sciences [q-bio], Molecular Sequence Data, Animals, Wild, Genome, Viral, SEQUENCE GENIQUE, VIRUS HEMORRAGIQUE DU LAPIN, [SDV] Life Sciences [q-bio], Sequence Homology, Nucleic Acid, DNA, Viral, Animals, Amino Acid Sequence, Rabbits

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