It is proved that it is possible to commuting self-adjoint operators two formally commuting Hermite operators, one of which is self-adjoint after closure and the other has equal defect numbers. The operators act in a Hilbert space constructed from the tensor product of two Hilbert spaces by completion with respect to a norm defined by a positive definite kernel which satisfies a certain majorizability condition. The result can be applied to a problem of integral representations and extensions of positive definite kernels.