Northern Chile, part of the south central Andes, consists of two main ecological subareas: extreme northern Chile, including the western valleys, and the Atacama Desert and oases. Different ecological conditions obtain in each subarea: puna, altiplano, and precordillera in the highlands; valleys, the desert, and oases in the intermediate zone; and coastal environments along the Pacific shores. In prehistoric times, all these environments were very interconnected. There are three different cultural traditions in the local prehistory: the early hunting and gathering tradition (10,000–4000 B.P.), the Chinchorro Tradition (7500–2500 B.P.), and the Altiplano or Andean Tradition (3000–0 B.P.). This proposed sequence is described, with emphasis on the early Chinchorro adaptations, including the important patterns of mummification, and its possible relation to tropical forest groups of the Amazon basin; and the Pre-Tiwanaku and later Tiwanaku and Inca developments, in relation to the circum-Titicaca region. The data presented in the paper are further developed to explore ideas and hypotheses for future research.