Effect of o,p-dichlorodiphenyldichloroethane and perthane in vitro on glutathione reductase activity in the adrenals of dogs and guinea pigs

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1978 English Publisher:Springer Science and Business Media LLCJournal:Bulletin of Experimental Biology and Medicine, volume 85, pages 152-154 (issn: 0007-4888, eissn: 1573-8221,

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Authors: V P, Komissarenko; I S, Chelnakova; A S, Mikosha;

doi: 10.1007/bf00800110

pmid: 630087

Effect of o,p-dichlorodiphenyldichloroethane and perthane in vitro on glutathione reductase activity in the adrenals of dogs and guinea pigs

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Abstract

Glutathione reductase is activated by o,p'-dichlorodiphenyldichlorethane (o,p'-DDD) and pertan added in a concentration of 312 micrometer to the homogenate and cytoplasmic fraction of the dog adrenals. At a concentration of 156 micrometer o,p'-DDD and pertan failed to influence the glutathione reductase activity of the dog adrenal glands. Added in vitro, o,p'-DDD and pertan activate glutatione reductase of the quinea pig adrenal glands. O,p'-DDD does not affect the glutathione reductase activity of the liver and kidney cytoplasmic fraction in dogs. This observation confirms the high specificity of o,p'-DDD action on the adrenal glands.

Related Organizations

Russian Academy of Sciences
Russian Federation

Keywords

Enzyme Activation, Dogs, Glutathione Reductase, Species Specificity, Adrenal Glands, Guinea Pigs, Animals, Mitotane

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