Vanadium phosphorus oxide (P/V = 1.1) was found to be active for NO reduction by butane to N2 at 766–816 K. The conversion increased with increasing butane concentration, increasing temperature, and decreasing NO concentration. The activity per surface vanadium ion compared favorably with other active catalytic systems, but was low in the absence of butane. Propane was also effective in reducing NO over this catalyst.