A group of male albino rats were subjected to the Maier paradigm (insoluble problem followed by a soluble problem) using the Lashley jumping stand. Forty-two animals which failed the soluble problem by adopting a position stereotype were then randomly assigned to eight drug groups in a 2×2 design. Animals were guided to the correct window on odd days but received no guidance on even days. Animals received either pilocarpine nitrate (5.0 mg/kg) or scopolamine hydrobromide (1.0 mg/kg) in one of three different sequences. These sequences included drug on both odd and even days (drug-drug), only on the odd day (drug-no drug), or only on the even day (no drug-drug). One other drug group received scopolamine methylbromide (1.0 mg/kg) in a drug-no drug sequence, while the control group received saline on both days. Results indicated that animals receiving pilocarpine in the drug-drug and no drug-drug sequence solved significantly faster than the controls, while all the drugno drug groups showed significantly poorer solution rates. It was concluded that pilocarpine may enable animals to inhibit punished behavior patterns and thus hasten the extinction of fixated responses, but that due to the inconclusive scopolamine data this pilocarpine effect may not be due to its cholinomimetic properties.