Three years' experience in teaching a course in Literature and Medicine is reviewed. Examples of the ‘Laboratory’ or ‘in vitro’ functions of art are given, as they relate to and benefit both medical students and practitioners. The usefulness of literature (especially) in the medical setting is underscored, together with the need for medical personnel to be more aware of their heritage in this area. Examples of well-known physicians who have excelled in the arts (literature, music, painting/sculpture) are given and their major contributions discussed. There are some surprises.