As regards motor-functions, we have noticed in normal subjects a real drop of the speed of tapping and an increase of the amplitude of the mistakes at mirror-drawing under the influence of thioridazine. As for personality we have noticed an increase of psychical tension at mirror-drawing and to the rating-scale and the notes depression and introversion at M.M.P.I. If we compare these results with those found on patients we come to think that the changes of personality brought by the drug are reactions secondary to a direct pharmacological reaction of thioridazine to the elementary level of impulses, vigilance or of psychomotion. A psychological conflict is necessary for the sedative effect of thioridazine to make good. In the case of a steady and level-headed subject the drug acts as a threat bringing negative reactions, an increase of anxiety. Yet the effects remain discrete at the quantity the drug is administered.