Initiation and promotion in hepatocarcinogenesis

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1987 English Publisher:Springer Science and Business Media LLCJournal:Archives of Toxicology, volume 60, pages 179-181 (issn: 0340-5761, eissn: 1432-0738,

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Authors: R, Schulte-Hermann;

doi: 10.1007/bf00296976

pmid: 3304207

Initiation and promotion in hepatocarcinogenesis

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Abstract

Initiation and promotion have been recognized as essential parts of the multi-stage concept of chemical carcinogenesis. In the liver, initiation by genotoxic carcinogens results in appearance of foci of phenotypically altered hepatocytes. Accelerated growth and phenotypic changes of these foci during tumor promotion by phenobarbital are described, and possible mechanisms of initiation and promotion considered.

Related Organizations

University of Vienna
Austria

Keywords

Liver Neoplasms, Experimental, Phenobarbital, Carcinogens, Animals, Mutagens

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