Human oncogenes

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1984 English Publisher:Springer Science and Business Media LLCJournal:Human Genetics, volume 66, pages 132-142 (issn: 0340-6717, eissn: 1432-1203,

Authors: K, Willecke; R, Schäfer;

doi: 10.1007/bf00286587

pmid: 6370829

Human oncogenes

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Abstract

The information published on human oncogenes up to the fall of 1983 is reviewed. Retroviral oncogenes, proto-oncogenes, and cellular transforming genes are compared. Transforming genes derived from the ras gene family are described in detail. The different mechanisms of activation of proto-oncogenes are summarized. Finally, the concerted or sequential action of cellular transforming genes in the multi-step process of carcinogenesis is discussed.

Related Organizations

University of Duisburg-Essen
Germany

Keywords

Genes, Viral, Turkey, Gene Amplification, Oncogenes, Cell Transformation, Viral, Translocation, Genetic, Cell Line, Rats, Mice, Tumor Virus Infections, Cell Transformation, Neoplastic, Retroviridae, Cebidae, Neoplasms, Mutation, Carcinogens, Cats, Animals, Humans, Chickens

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