Kalanchoe brasiliensis Cambs. and Kalanchoe pinnata (Lamk.) Pers species belong to Crassulaceae family. Kalanchoe brasiliensis is popularly known as ‘saiao’, ‘white coirama’, ‘thick leaf’, ‘leaf of luck’ and ‘leaf of the coast’, and Kalanchoe pinnata as ‘saiao-roxo’, ‘leaf-of-fortune’, ‘leaf of the coast’, ‘yellow flower of fortune’ and ‘para-tudo’. In ethnopharmacology, there are reports of the use of the extract of the leaves of Kalanchoe brasiliensis for skin infections and oral mucosa, bronchitis, nasal congestion, chest infections, yellow fever, gastric ulcers and arthritis. Leaves and stalks are the most commonly used parts. The leaves of K. brasiliensis contain high concentrations of flavonoids; while fatty acids, acyclic and aromatic organic acids, amino acids, bufadienolides, α-β unsaturated acyclic ketones, fenantrenic derivatives, sterols, long-chain hydrocarbons and triterpenoids are found mainly in the leaves of K. pinnata. Analgesic, anti-inflammatory, antileishmaniotic, antimalarial, antipyretic, antimicrobial, antithyroidal, antitumor, antiulcer, hepatoprotective, immunosuppressive, pesticide, inhibition in uterine contractions, neuropsicofarmacologic and hypoglycemic properties of these species have already been evaluated in experimental pharmacology.